It happened at the intersection of Williamson Drive and Westney Road.
Police are saying this morning that a female driver was in one of the vehicles and that the other vehicle was carrying four males.
The one male that went to the hospital has succumbed to his injuries a short time later.
The circumstances leading up to the collision remain unclear at this point.
The Durham Regional Police Traffic Services Unit will be conducting an investigation at the scene please avoid the area.
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